When N,N‐dialkylamide dimethylsulfate adducts are reacted with cyanoacetyl urea or carbethoxy acetyl urea, the corresponding dialkylamino alkylidene derivatives are formed which cyclize to substituted uracils in the presence of a strong base. When the adducts of cyclic amides are used, the lactam ring is opened simultaneously on cyclisation.
Durch Reaktion der Dimethylsulfat‐Dialkylamid‐Addukte (I) mit dem Harnstoff (II) in DMF werden die Zwischenprodukte (III) erhalten (nicht isoliert), die sich beim Erhitzen mit Na‐methylat/Methanol zu den Pyrirnidinsalzen (IV) cyclisieren; diese werden mit HCl zu den Uracilen (V) (2"l‐93% Ausbeute) hydrolysiert.
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