We report a highly efficient, one-pot, three-component condensation of carbonyl compounds, amines, and TMSCN in MeCN; the reaction is significantly promoted by the catalytic amount of cerium(III) chloride at ambient temperature in excellent yields without any adverse effect on the other substituents. The method afforded an elegant alternative to the synthesis of a-aminonitriles. The reactions are fast and clean, and the products obtained are of high purity.
Various azoarenes undergo reductive fission with hydrazine hydrate in refluxing ethanol to give easily isolable aminoarene(s) using aluminium powder. The reaction is fast and cost effective: yields are excellent ranging from 85-95%; substituents like -OH, -OCH 3 , -COOH, -Cl, -Br are unaffected. The method affords a simple and convenient route to the preparation of substituted aminoarenes.
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