1. Chronic oxytetracycline treatment was found to improve the insulin resistance of the obese-hyperglycaemic mouse. 2. The improved response to insulin was accompanied by decreased concentrations of circulating insulin and glucose, by a decrease in the lipid content of the liver and by an increase in the insulin-receptor sites of the liver and adipose tissue. 3. The increase in insulin-receptor sites preceded the fall in blood glucose. 4. Comparable studies done on food-restricted animals indicated that although chronic food restriction corrected the hyperinsulinaemia it did not restore the insulin-receptor sites or the hyperglycaemia.The obese-hyperglycaemic mouse is characterized by obesity, non-ketotic hyperglycaemia, hyperinsulinism, islet-cell hyperplasia and resistance to exogenous insulin. Insulin resistance in the obesehyperglycaemic mouse has been attributed to several factors.(1) The number of insulin-binding sites on
Forty-two species of yeast were examined for their ability to produce enediols of the ascorbic acid class. A Roe and Kuether chromogen derived from such enediols could be isolated from 23 of the species. The chromogen from four yeasts was further identified by infrared (i.r.) spectrophotometry as being derived from ascorbic acid. At least one species from each family of yeasts was found to produce ascorbic acid.
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