The wild vine Vitis tiliifolia is found in Mexico, Central América, and the Caribbean region. In the Veracruz State, in Mexico, grows in several municipalities and is used for nutritional and therapeutic purposes. The geographical distribution and environment where this Vitis grow has not been recorded. The leaves of V. tiliifolia are rich in phenolic compounds but potential areas with vines of high phenolic compounds are unknown. An agroecological zoning model to identify potential areas for the cultivation and development of this species was performed. Potential areas having wild vines of high phenolic compounds in the leaves were also determined. The model included 95 vine georeferences, obtained from four municipalities of central Veracruz. These were analyzed with maximum entropy modeling, mapped with ArcMap software, and correlated with the phenolic compounds found in leaves collected in the georeferenced areas. A zoning map was produced, with a potential area of 2763.72 km2, which included the states of San Luis Potosi, Hidalgo, Veracruz, Puebla, Oaxaca, and Chiapas. Agroclimatic variables of seasonality of temperature, precipitation, and organic matter in the soil were the most important for the development of this species. In the state of Veracruz, vines with the potential of high phenolic content were found in 29 municipalities with characteristics suitable for its cultivation. The highest phenolic content potential was found at altitudes between 1000 and 2000 meters in the municipalities of Huatusco and Cosautlán in the State of Veracruz.
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