A non-consanguineous couple requested prenatal diagnosis because the woman's brother had Down's syndrome. Paternal and maternal ages were 32 and 30, respectively. They already had a normal daughter.Amniocentesis was performed during the 16th week of gestation; only mild oligohydramnios was noted.During the 20th week, the cytogenetic results were received (46,XX) but ultrasound showed that both biparietal and abdominal diameters were on the 5th centile, while the femoral length was on the 50th centile. Three weeks later another ultrasound scan showed that both the abdominal and biparietal diameters were below the 3rd centile; the femoral length was normal. This intrauterine growth
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