The acute toxic effects of different doses of methanolic leaf extract of Trevesia palmata (METP) was studied in rats. The oral administration of different doses of Trevesia palmata did not show any mortality upto 2000mg/kg b.wt. orally in rats. Therefore, it was concluded that METP was found to be safe as such and did not have any toxic manifestations upto the dose of 2000 mg/kg b. wt. Hence 1/10th (200 mg/kg, po) and 1/5th (400 mg/kg, p.o) of this dose were employed for further pharmacological investigations. The methanol extract of Trevesia palmata was estimated for various biochemical and Haematological parameters. The administration of different doses of METP showed a significant decrease as compared to Control as indicated by lower activities of Serum Glutamic Oxaloacetic Transaminase (SGOT) or Aspartate Aminotransferase (AST) , Serum Glutamic Pyruvic Transaminase (SGPT) alkaline phosphatase (ALP) enzymes, total bilirubin, total Cholesterol and albumin, in rats along with the elevation of total proteins, content. Similarly, The results of the haematological parameters showed that the mean RBC and Hb concentrations increased significantly (p<0.05) at 200mg/kg and 400mg/kg of administration. The eosinophil count was decreased significantly at 200mg/kg and 400 mg/kg of administration (p<0.05). Neutrophil and lymphocytes did not show significant difference at all doses of administration. There was no significant difference in RBC, Hb concentrations as well as the eosinophil at 200mg/kg and 400mg/kg of administration. In this study, significant increases in RBC, WBC, Hb at 200mg/kg and 400mg/kg were observed. This may be due to the presence of erythropoietin-like principals in the extract which probably stimulated erythropoietin synthesis or release at minimal doses (200mg/kg and 400mg/kg).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.