Baby mice, a few hours old, were infected intracerebrally with the mouse-adapted strain ‘F’ of ‘Marburg virus’. 4, 8 and 11 days thereafter the animals were sacrificed and examined histologically as well as mice which died after 11 days post infectionem. From the histological examination it can be concluded that 8 days p.i. a spotted polioencephalitis develops in relation to the blood vessels. However, 11 days p.i. a panencephalitis was observed. Only weak defense mechanisms of the brain tissues were found. All the other inner organs examined were free of pathological alterations. Differences to other well-known experimental encephalitides are discussed.
A 29-year-old Ukrainian woman presented to the obstetric clinic at 28 weeks' gestation with pregnancy complicated by intrauterine growth restriction. She reported progressively worsening dyspnea during her pregnancy and was found to have significant hypoxia with an oxygen saturation of 84% on room air prompting admission for further evaluation. Oxygen saturation improved to 92% on 10 L of supplemental oxygen. On further questioning, she was found to have a history significant for pleurodesis as a treatment for recurrent pneumothoraces and nephrectomy for a benign renal mass several years prior while living in Ukraine.
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