Serum concentrations of lipids and apolipoprotein A-I, A-II and B were determined in patients with hepatic metastases of colorectal cancer, with primary liver cancer and with cirrhosis.In all three liver diseases, the HDL fraction and apolipoproteins A-I and A-II showed significantly low values, while apolipoprotein B was only increased in hepatic metastases.The decrease of apolipoprotein A-II levels was more prominent in cirrhosis, thereby enhancing the A-I/A-II ratio. This ratio is decreased in metastasis and normal in hepatomas.In patients with hepatic metastases a correlation was observed between alkaliiie phosphatase and apolipoprotein A-II (p < 0.05), and between -glutamyltransferase and the A-I/A-II ratio (p < 0.05).The-present work suggests that determination of apolipoproteins and lipids of the HDL fraction offers a new approach to the study of liver diseases.
Serum concentrations of total cholesterol and lipoprotein cholesterol, of apolipoproteins AI and AII and of apolipoprotein AI in lipoprotein particles (Lp AI and Lp A) were determined in 43 patients with multiple myeloma.There were striking alterations in the plasina levels of these analytes relative to normal subjects.We observed a decrease of cholesterol levels in LDL, HDL and HDL 3 fractions, and of apolipoproteins AI and AII compared with normal subjects. The HDL 2 cholesterol was increased.The decrease of apolipoprotein A II was more prominent than apolipoprotein AI.The decrease of apolipoprotein A I concerns only the A I (Lp A), while the AI (Lp AI) was increased.Most of these modifieations were correlated with the monoclonal Ig levels.
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