PURPOSE: Adiponectin is a protein stemming from adipose tissue and having strong anti-infl ammatory properties. We aimed to assess the damage diminishing effects of recombinant adiponectin (rAD) through NF-kB in the experimental acute pancreatitis (AP) model. MATERIALS AND METHODS: Acute pancreatitis was created by applying 50 μg/kg dose of intraperitoneal cerulean. The rats were randomised and divided into 3 groups as control, AP and rAD groups. Moreover, the rats in each group were divided into two subgroups as 24th and 48th hour subgroups. rAD was injected in the study group intraperitoneally. Tissue and blood samples were taken after 24 and 48 hours. Histopathological assessment and NF-kB activity were investigated in pancreatic tissue. RESULTS: Serum TNF-a, IL-1b and IL-6 levels were found to be statistically signifi cant in the AP group compared to the rAD group in the 24th and 48th hour (p < 0.05). Similarly, NF-kB activity was also found to be signifi cant in the AP group both in the 24th and 48th hour (p < 0.05). There were signifi cant differences in the AP and the rAD groups histopathologically in terms of edema, infl ammation, vacuolisation and necrosis (p < 0.001). CONCLUSION: rAD has signifi cantly reduced NF-kB activity, cytokine levels and tissue damage (Tab. 1, Fig. 1, Ref. 51).
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