We studied 26 formalin-fixed biopsy specimens taken from 22 patients with scleredema and found positive staining in 67% of the tissues when both colloidal iron and alcian blue methods were used. Single stains were positive in only half the tissues. Positive findings were noted in both patients with diabetes (11 patients) and in those without it (11 patients). Our experience indicates that multiple biopsies may be necessary to demonstrate mucin in the dermis. Specimens obtained by incisional biopsy are preferred.

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Interatomic-force constants may be predicted from standard central-force laws using thermodynamic data. For the three cases where diffraction data are available (aluminum, copper, and iron) the predicted values agree within an order of magnitude for aluminum and iron, but diHer strongly in the case of copper. It is suggested that Jacobsen's al, for eepper, represents the strongest departure from a centralforce model and should therefore be the most promising point for further theoretical work. mn [ 1 (ro,)m I (1'0' ')" ] <,1,(r) = --fL' ---

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