Combined congenital abnormalities of the skin and central nervous system are well recognized-such conditions as Sturge-Weber syndrome, tuberous sclerosis, and neurofibromatosis. A very much rarer and less well-known member of this group is neurocutaneous melanosis. posterior fossa decompression was performed, and it was noted at operation that the meninges overlying the cerebellum were thickened and pigmented. The underlying cerebellar cortex also appeared to be pigmented. After operation the child renained well for eight weeks, but it was then noted that he was ataxic and though he was talking well he was emitting a shrill high-pitched cry at frequent intervals. The posterior fossa decompression was tense and bulging, and a Pudenz valve was therefore inserted into the right lateral ventricle draining into the right internal jugular vein. The child then remained fairly well, apart from some degree of ataxia, for a further period of four months, when he was readmitted with increasing restlessness, ataxia, and rigidity. The posterior fossa decompression was again tense and bulging, and at operation the Pudenz valve was found to be blocked by a protein coagulum, and it was replaced. Three days after the operation the child's conscious level began to decline:he developed left-sided Jacksonian epileptiform attacks and, despite repeated ventricular taps, died at 25 months.NECROPSY. There were no abnormal pathological findings outside of the skin and the central nervous system. In particular, no evidence of tumour was found in any other organ. The skin showed numerous large pigmented hairy naevi on the skin of the limbs, chest, trunk, back, and scalp. These varied in size, but ranged up to a maximum diameter of 6 cm.The dura appeared normal and showed no evidence of pigmentation, but the pia-arachnoid showed a diffusely. grey coloration most marked over the right cerebral hemisphere. In addition there were numerous scattered FiG.

The rising incidence of male urethral infection of uncertain aetiology is at present a major problem. The reported figures for non-gonococcal urethritis in England and Wales increased in the 20 years from 1951 to 1970 by nearly 38,000, most of these cases being of the non-specific variety. There are epidemiological reasons for thinking that non-specific urethritis (NSU) has its counterpart in women as nonspecific urogenital infection (King, 1972). For notification purposes, the condition in both sexes is now referred to as non-specific genital infection (NSGI) with, or without, arthritis. In England in 1971 the venereal disease clinic returns for "NSGI without arthritis" totalled 59,023 for men and 13,397 for women (Department of Health and Social Security, 1972).The difficulty in defining the clinical disorder in women has contributed to the problem (Catterall, 1971;Department of Health and Social Security, 1970; Brit. med. J., 1971a;Nicol, 1971 Inflammatory disease of the cervix is often seen in the course of routine examination of women in general practice. In the present investigation an attempt has been made to relate this to possible unsuspected NSU in their male consorts. In addition, the effect of the condom in reducing the frequency of NSGI has been studied. Material and methodsThis study was conducted in a predominantly workingclass practice in London. During the investigation 325 women were studied; 80 per cent. were in their third or fourth decade and 95 per cent. were married. 98 women (30 per cent.) were examined because they complained of urogenital symptoms; 227 women (70 per cent.) presented without symptoms and were examined routinely, e.g. for post-natal check, contraception, and periodic cervical cytology. Couples, either partner of whom had had systemic antibiotics within 3 months of examination, and pregnant women have been excluded from this report.When these 325 women were examined, it was explained that tests involving both sexual partners would be done "to exclude inflammation". In every case women were asked about a past history of genital disorders and for details of recent sexual contact and contraceptive technique.Clinical examination With the woman in the dorsal position, the external genitalia were examined and cleansed and the vagina and cervix inspected via a Cusco's speculum. Specimens were collected as follows: (1) A scrape from the squamo-columnar junction of the cervix was spread with an Ayre's spatula on a glass slide and fixed for cytology.(2) Vaginal, cervical, urethral, and rectal specimens were spread on glass slides; further specimens from the vagina, cervix, and occasionally the urethra and rectum

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