Short oligocytidylates can act as templates for the self-condensation of guanosine 5'-phosphorimidazolide. In the absence of a catalytic metal ion or in the presence of Pb2+ a noticeable template effect is already observed with the dimer and the yield of long oligomers reaches a plateau with a hexamer template. Short templates give oligomers longer than the template length. The products are predominantly 2'-5' linked for the Pb2+-catalyzed reaction while mixed linkages are observed in the uncatalyzed reaction. In the presence of Zn2+, a template effect is first observed with the pentamer and is maximal by the heptamer. The products are predominantly 3'-5' linked. Oligomers shorter than or as long as the template are obtained in substantial yield, and longer products in much lower yields.
Die Oligomerisierung des Guanosinphosphats (I) an einem Polycytidylsäure‐Template erfolgt in effizienter Weise bei 37°C, obwohl der vom Template und Substrat gebildete helikale Komplex bei viel niedrigerer Temp. schmilzt.
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