MICs of 20 2-acetylpyridine thiosemicarbazones and penicillin were determined for 25 clinical isolates of I8-lactamase-positive and P-lactamase-negative Neisseria gonorrhoeae strains. The compounds most active against the I8-lactamase-producing strains were the N4,N4-disubstituted derivatives and the thiosemicarbazone derivatives of the 2-acetylpyridines, followed by the other compounds related to the 2-acetylpyridine thiosemicarbazones.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.