Background: Octocrylene is a new emerging photoallergen. We report and discuss 50 cases of photoallergic contact dermatitis from octocrylene use and/or positive photopatch test reactions to this UV filter and draw attention to the unexpected association in adults with a history of photoallergic contact dermatitis from ketoprofen.Observations: Patients were divided in 3 groups: group A comprised 11 children; group B, 28 adults with a history of photoallergy from sunscreen products; and group C, 14 adults systematically tested with octocrylene because of a history of photoallergy from ketoprofen. All patients but 3 in group C had positive test reactions to octocrylene. Ten of 11 children in group A and 9 of 28 adults in group B had positive patch test reactions to octocrylene. One child in group A, the other 19 adults in group B, and 11 of 14 adults in group C had positive pho-

Vemurafenib is a new-targeted therapy approved for the treatment of patients with V600E BRAF-mutant metastatic melanoma. Among the cutaneous adverse events reported, the photosensitivity is frequently experienced. We aimed to characterize more deeply the mechanism leading to this photosensitivity as well as the corresponding UV spectrum. Phototests showed that the phototoxicity was UVA-dependent since from normal value prior to vemurafenib treatment, the UVA-minimal erythema dose decreased in 17 of 18 patients (94.4%) while the minimal erythema dose remained unchanged. Furthermore, a vemurafenib-induced erythema appeared quickly during the UVA exposure contrarily to what is observed with a conventional drug-induced phototoxicity showing an erythema 12-24 h after the phototesting. Vitamin PP concentration decreased, and porphyrin level significantly increased after 2 months of vemurafenib. Our study confirms the high risk of vemurafenib-induced photosensitivity and indicates that it is possibly vitamin PP-and porphyrin dependent.

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This study proposes a benefit of natural progressive sun exposure for patients with EPP.

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In Europe, contact photosensitivity to phenothiazines is known particularly in southern countries. Topical phenothiazines are widely used and sold over-the-counter for the treatment of mosquito bites and pruritus in France. Objective:To report a series of cases with photodermatitis to topical phenothiazines. Method:A retrospective study of cases of contact dermatitis to phenothiazines seen in French photodermatology centres was performed. Results:In all, 14 patients with the diagnosis of contact dermatitis to phenothiazines were included. These developed eczema on the application sites, and in 13 the eruption spread to photodistributed sites. Topical products containing isothipendyl were the most common cause of photodermatitis. One patient had photoaggravated eczema due to promethazine cream. All patients stopped using topical phenothiazines and were treated successfully with topical corticosteroids. One patient relapsed and developed persistent light eruption. In all of the 9 cases tested, photopatch testing to the topical phenothiazine used "as is" was positive.Isothipendyl, chlorproethazine and the excipients were not tested. Photopatch tests to chlorpromazine and promethazine were positive in 8/12 and 7/13 tested respectively. Conclusion:Use of isothipendyl and promethazine as over-the-counter (or even prescribed) drugs needs to be limited due to severe reactions and sensitization to other phenothiazines that otherwise will have to be avoided.

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