Crystals of the diuretic furosemide, C 12 HI 1C1N205 S, are triclinic, space group P i, with a = 10.467 (12), b = 15.801 (15), c = 9.584 (10) A, a = 71.87, fl = 115.04, y = 108.48 °. The structure was solved by direct methods and refined by least-squares procedure to a final R value of 6.8 % for 4135 observed reflections. The H atoms were included in the calculation. Without the furan ring, the two independent molecules are related by a pseudocentre of symmetry which was found between the carboxylic groups.
KATSUO KATO, ISAO KAWADA UND TATSUO TAKAHASHI 3443 den unter Annahme dieses Atomformfaktors verfeinerten Angleichungsfaktoren ffir die Reflexgruppen mit k -0(mod 3) und k ---0(rood 5) steht mit dem experimentell ermittelten Weft im Einklang. Die aus dem obengenannten 'Zellinhalt' errechnete Dichte betriigt 4,53 g cm -3 und stimmt mit dem von Takahashi et al. (1971) Glycyrrhetinic acid acetone monohydrate (1 : 1 : 1) crystallizes in the orthorhombic space group P21212 with a = 11.541, b = 36.328, c = 7-406 A. The crystal structure was solved by direct methods and refined to R = 0.057 for 2573 reflexions. All the molecules are linked together by hydrogen bonds; water plays a particularly important role in the crystal packing. Conformational similarities between glycyrrhetinic acid and mineralocorticoids are emphasized.
Strychnofoline is a phenolic alkaloid isolated from leaves of Strychnos usambarensis. The crystals of C30H34N40 2 .2C2H60 are monoclinic, space group P2~, with a = 9.019 (3), b = 17-941 (5), c = 10-598 (3) ,~ and/3 = 99.69 (3) °, Z = 2. The crystal structure has been solved by direct methods, and refined with a blockdiagonal least-squares method to a final R value of 7.3% (2820 reflexions). The configuration determined by biogenetic arguments is 3S,4R,7S, 15S, 17S,20R. This is the first oxindole found in a strychnos.
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