Organic arsenicals are widely used as growth promotants and disease-control agents in feeds. Data on differences between the action of arsonic acids and antibiotics were sought, as well as differences between arsenicals themselves. There appears to be no good rationale why some arsenicals promote growth and others do not. Arsanilic acid and 3-nitro-4-hydroxyphenylarsonic acid, both arsonic acids but differing in potency and in toxicity, have been most widely studied. Toxicity of arsenicals is a direct consequence of the arsenic which reaches vital tissues. Arsanilic acid, which is well tolerated in chickens, turkeys, swine, and dogs, gives low tissue arsenic levels. Arsanilic acid did not interfere with reproduction over three generations in rats. Unlike antibiotics, arsonic acids do not lessen the need for vitamin Bi2. Organic arsenicals provide important aids to animal production distinct from the antibiotics. That they can be safely used, with adequate controls and proper precautions, has been demonstrated.
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