No abstract

A genomic clone containing two linked human pregnancy-specific (31-glycoprotein (PSI3G) genes has been isolated and characterized. The two genes are arranged in the same 5' -+ 3' orientation; the 3' region (including the A2and B-C exons) of the upstream gene, PSGGA, is linked to the 5' region (including the 5'/L and L/N exons) of PSGGB, the downstream gene. Depending upon the domains compared, PSGGA and PSGGB share 92-98% nucleotide and 86-95%

No abstract

No abstract

Key wordsThe medical records of patients with bipolar disorders who received prophylactic drug treatments during three time periods from January 1983 to December 1984. January 1988 to December 1989, and from January 1993 to December 1994. were reviewed retrospectively. The percentage of lithium monotherapy sharply decreased from 96% (51/53) in the first study period to 51.9% (83/160) in the third study period. Carbamazepine monotherapy and combination of lithium and carbamazepine increased from 3.8% in the first study period to 45.6% in the third study period. These results suggest that anticonvulsants may become one of the major drug treatment strategies for bipolar disorder in the future. bipolar disorder, carbamazepine. lithium, trend, valproate.