A121effects other than bleeding and thrombosis (38.5% vs. 16.7%, p= 0.004). Patients on TSOAC had a lower [better] mean QoL summary score compared to warfarin treated patients (39.2±11.3 vs. 46.8±19.8, p= 0.01). Based on the results of the unadjusted linear regression model, patients treated with TSOAC had significantly better DASS QoL summary score (β = -7.65, 95% CI: -13.49, -1.82, p < 0.05); however, after adjusting for differences in patient groups, the effect of TSOAC on QoL became non-significant (β = 4.47, 95% CI: -5.06, 14.00, p= 0.35) ConClusions: Differences in social-demographic characteristics between patients treated with warfarin and TSOAC were observed in an inner-city population. After adjusting for patient social-demographic characteristics, TSOAC had no impact on treatment-related QoL.
ObjectivesA subset of primary central nervous system lymphoma (PCNSL) has been shown to undergo an early relapsed/refractory (R/R) period after first-line chemotherapy. This study investigated the pretreatment clinical and MRI features to predict R/R in PCNSL, emphasizing the apparent diffusion coefficient (ADC) values in diffusion-weighted imaging (DWI).MethodsThis retrospective study investigated the pretreatment MRI features for predicting R/R in PCNSL. Only patients who had undergone complete preoperative and postoperative MRI follow-up studies were included. From January 2006 to December 2021, 52 patients from two medical institutions with a diagnosis of PCNSL were included (median follow-up time, 26.3 months). Among these, 24 (46.2%) had developed R/R (median time to relapse, 13 months). Cox proportional hazard regression analyses were performed to determine hazard ratios for all parameters.ResultsSignificant predictors of R/R in PCNSL were female sex, complete response (CR) to first-line chemotherapy, and ADC value/ratio (p < 0.05). Cut-off points of ADC values and ADC ratios for prediction of R/R were 0.68 × 10−3 mm2/s and 0.97, with AUCs of 0.78 and 0.77, respectively (p < 0.05). Multivariate Cox proportional hazards analysis showed that failure of CR to first-line chemotherapy and low ADC values (<0.68 × 10−3 mm2/s) were significant risk factors for R/R, with hazard ratios of 5.22 and 14.45, respectively (p < 0.05). Kaplan–Meier analysis showed that lower ADC values and ratios predicted significantly shorter progression-free survival (p < 0.05).ConclusionPretreatment ADC values in DWI offer quantitative valuable information for the treatment planning in PCNSL.
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