Regular exercise is recommended to improve immune system function and antioxidant activity, while conversely, it may cause inflammation by increasing neutrophil-derived main enzyme, myeloperoxidase, which produces reactive oxygen species. The present study aimed to investigate changes in myeloperoxidase level, its influence on total oxidant status, and the capacity of the antioxidant defence system to counteract oxidative stress in middle-aged men participating in leisure-time regular exercise compared to untrained peer subjects. Twenty trained (age 53.58±2.94 years, body mass index (BMI) 25.47±1.6) and 17 untrained (age 54.17±2.83 years, BMI 27.83±1.12) healthy middle-aged men participated in this study [Rasht, Gilan, Iran]. Participants performed a modified Bruce treadmill test as a model of progressive exercise training. Blood samples were taken before, immediately after, and one hour after the end of the test. A mixed ANOVA and Bonferroni post hoc test was used for the analysis of variables. A significant difference was observed in myeloperoxidase levels between groups, while the trained group showed a significantly lower concentration than the untrained group (P<0.018). This result was also consistent with the lower total oxidant status in this group (P<0.001). Total antioxidant capacity changed significantly in both groups with higher concentration in the trained group (P<0.001). The leisure-time regular exercise can reduce myeloperoxidase concentration and total oxidant status in healthy middle-aged men while increasing the total antioxidant capacity, which may potentially protect them from the side effects of immune system activity induced by exercise training.
Objectives The present study aimed to explore the effect of water-based rhythmic exercise training on fasting blood sugar (FBS), homeostatic model assessment (HOMA), insulin, thyroid stimulating hormone (TSH), and T4 in postmenopausal women with metabolic syndrome. Methods In this clinical trial, 31 postmenopausal woman with metabolic syndrome aged 69.16 ± 2.02 years were randomly assigned to an experimental (n=16) and a control group (n=15). The training program was composed of 12 weeks of water-based rhythmic exercise training performed intermittently for 60 min three times a week. Before and after training, blood was analyzed for glucose homeostasis, T4, and TSH. Data were subjected to analysis by paired t-test and covariance analysis at the p<0.05 level. Results The exercise training intervention reduced the FBS and insulin significantly (p=0.000). The growth hormone (GH) index was increased significantly only in the experimental group (p=0.037) whereas no significant variations occurred in the insulin-like growth factor-1 (p=0.712). It was also found that TSH and T4 change in the experimental group as compared to the pre-test. Conclusions Water-based rhythmic exercise training may improve blood glucose homeostasis, TSH, and T4.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
334 Leonard St
Brooklyn, NY 11211
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.