Covid-19 is an inflammatory disease primarily affecting the respiratory system, but can affect multiple organs causing multiple organ failure. Thrombosis is a major prognostic complication during SARS-Co-2 infection. We report the case of a young patient consulting for an acute febrile abdomen, whose abdominal CT scan showed extensive porto-mesenteric thrombosis. A systematic Covid-19 PCR test coming back positive. The assessment objectified a positive JAK2 mutation. This reflects the interest of broad screening for SARS-Cov-2 infection, by PCR test and initial imaging aimed at looking for thromboembolic disease, and of a comprehensive etiological approach.
Keywords: SARS-Cov-2 infection, Thromboembolic disease, PCR Covid-19, systematic screening, Extensive thrombosis, mortality, JAK2.
MAIS is a rare entity, characterised by a combination of several autoimmune disorders. It is divided into three groups. Biermer disease (BD) belongs to MAIS 3 and is an autoimmune atrophic gastritis causing vitamin B12 deficiency, often associated with autoimmune diseases. The most frequently described are endocrinopathies, dominated by autoimmune thyroiditis followed by type 1 diabetes. Others have been reported, such as vitiligo, Gougerot-Sjögren syndrome and systemic lupus erythematosus. The coexistence of Biermer disease, AHAI or Biermer disease, primary biliary cirrhosis (PCB) and immunological thrombocytopenicpurpura (ITP) is rare. The diagnosis of Biermer's disease therefore requires systematic screening for other autoimmunedisorders.
Keywords: multiple autoimmune syndrome, Biermer disease, autoimmunity, atrophicgastritis, replacement therapy.
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