A method i s described for determining active hydrogen by means of the reaction of the unknown substance with a suspension in pyridine of the Grignard-pyridine complex. The apparatus and procedure are derived from those of Fuchs, Ishler, 4nd Sandhoff (2) with substantial modifications. The results are satisfactory and the use of pyridine makes the technique available for the analysis of an extensive series of organic compounds.
Das durch Birch‐Reduktion mit Lithium in flüssigem Ammoniak aus Phenylglycin darstellbare Cyclohexadienylglycin (I) wird in Form seines Natriumsalzes mit Acetessigsäuremethylester zu dem Enamin (II) umgesetzt und dieses mit 6‐Aminopenicillansäure (III) bei ‐20 bis ‐10°C zu dem Penicillinderivat (IV) kondensiert.
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