A patient with several congenital malformations, principally in the face, cardiovascular system and genitalia, was found to have the karyotype46,X,der(X),t,X;3)(Xqter← p21::3ql2‐←3qter). A comparison of the clinical and cytogenetical findings with similar cases in the literature led to the conclusion that a partial trisomy 3q is the most likely cause for the symptoms in this patient.
Cyclic fluctuations were studied in the activity of oxidoreductases playing a role in the major energy metabolic pathways, lysosomal and non-lysosomal hydrolases and some non-enzymatic cytochemical components demonstrable in different developmental physiological or pathophysiological phases of human endometrium. The total scope of the study involved 170 tissues and cytological specimens. The cytological material included microcurettings, aspirates, brush preparations and tissue prints. An evaluation of the usefulness of the application of enzyme cytochemistry to cytological material is included. The most important results were a cyclic fluctuation and a progestagenic controlled increase in the activity of many oxidoreductases, especially the NADPH regenerating enzymes of the pentose phosphate pathway, and of the NADP+ dependent isocitrate dehydrogenase. The histochemical evaluation of the activity of these NADP+ linked enzymes can therefore be recommended for the evaluation of the physiological status of the endometrial cells, especially in patients with infertility problems.
SUMMARY In a series of 42 patients with endometrial adenoacanthoma and of 53 with adenocarcinoma, age at the time of diagnosis, age at the onset of the menopause, gravidity, pathological staging, and survival were compared to see if there was any significant difference, apart from morphology, between the two tumours. No significant differences could be established, and it was concluded that adenoacanthoma should be regarded as a histological variant of adenocarcinoma and not as a separate entity.
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