Two patient receiving minocycline developed blue-black pigmentation on the legs. Biopsies from the pigmented areas demonstrated granules containing iron, a pigment with staining properties similar to melanin, and a third pigment which may be a degradation product of minocycline. Electron microscopy showed that some, but not all the granules were membrane-bound and they were situated mainly within macrophages. Analytical electron microscopy showed that the granules contained iron, sulphur, chlorine and, in one case, calcium.
Forty cases of a distinctive acervate epidermal tumour (intra-epidermal epithelioma of Jadassohn) are described. The pathological and clinical features distinguishing it from other skin tumours are emphasized. Invasive areas were found in five of the cases, one with metastasis to a lymph node, underlining the need to differentiate this tumour from benign epidermal tumours, such as 'irritated' seborrhoeic keratosis and inverted follicular keratosis with which it has been and still is frequently confused.
Three cases of micropapular sarcoidosis are reported. Two of the cases have a history of tuberculosis and all three cases have atypical patterns of Kveim and Mantoux reactivity. The similarities between this form of sarcoidosis and lichen scrofulosorum or lichenoid tuberculid are observed and the evidence is presented for a tuberculoid aetiology in certain forms of sarcoidosis.
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