Acalypha wilkesiana has been used for various medicinal purposes such as in the treatment of hypertension, fungal and bacterial infections. In this study, the effects of prolonged oral administration of the aqueous leaf extract on some biochemical profiles of mice were evaluated. A total of 80 mice were allocated to 4 groups (A, B, C and D) comprising of 20 mice each. Mice in group A (control) were given (1 mL) of distilled water orally while 1 mL of the extract was given to the mice in groups B, C and D daily at the concentrations of 800, 1000 and 1200 mg/kg, respectively. This was continued for three weeks and at the end of each week, 4 mice from each group were humanely sacrificed and sera from blood samples collected were used for determination of activities of biochemical parameters. The results showed that administration of the extract resulted in significantly (p < 0.05) lower concentrations of total protein and cholesterol in the treatment groups at the 3rd week of treatment when compared to control values. Glucose level was significantly (p > 0.05) higher in the extract-treated groups by the 3rd week of treatment, while activities of AST, ALT and ALP were not significantly (p > 0.05) altered by the extract. There were no significant (p > 0.05) differences between the levels of calcium, total and conjugated bilirubin in treatment and control groups, while sodium concentration was significantly (p < 0.05) higher at day 14 after withdrawal of treatment, compared to the control. This study suggests that the extract of Acalypha wilkesiana has a hyperglycaemic effect.
Objective: Objective of present study was to evaluate the efficacy and safety of on some Acalypha wilkesiana haematological parameters in mice. The oral acute toxicity (LD) was studied using the Materials and Methods: 50 method of Kaber as modified by Aliyu and Nwude. The effects of the aqueous extract of leaves Acalypha wilkesiana on some haematological parameters in mice were studied. The oral LD with 95% confidence interval of the Results: 50 aqueous leaf extract was estimated to be 1420mg/kg, indicating that the extract is not toxic. After prolonged oral treatment of mice with the leaf extract, significant increases in the levels of mean Hb concentration, RBC, and PCV were observed. This study suggests that the aqueous leaf extract of contains some Conclusion: Acalypha wilkesiana important chemical components which may have therapeutic values and have some beneficial effects on haematological parameters, suggesting that it could be used as an anti anaemic.
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