In view of the long-recognized difficulties in detecting interactions among continuous variables in moderated multiple regression analysis, this article aims to address the problem by providing feasible solutions to power calculation and sample size determination for significance test of moderating effects. The proposed approach incorporates the essential factors of strength of moderator effect, magnitude of error variation, and distributional property of predictor and moderator variables into a unified framework. Accordingly, careful consideration across different plausible and practical configurations of the prescribed factors is an important aspect of power and sample size computations in planning moderated multiple regression research. The performance of the suggested procedure and an alternative simplified method is illustrated with detailed numerical studies. The simulation results demonstrate that an acceptable degree of accuracy can be obtained using the recommended method in assessing moderated relationships.
Moderated multiple regression (MMR) is frequently employed to analyse interaction effects between continuous predictor variables. The procedure of mean centring is commonly recommended to mitigate the potential threat of multicollinearity between predictor variables and the constructed cross-product term. Also, centring does typically provide more straightforward interpretation of the lower-order terms. This paper attempts to clarify two methodological issues of potential confusion. First, the positive and negative effects of mean centring on multicollinearity diagnostics are explored. It is illustrated that the mean centring method is, depending on the characteristics of the data, capable of either increasing or decreasing various measures of multicollinearity. Second, the exact reason why mean centring does not affect the detection of interaction effects is given. The explication shows the symmetrical influence of mean centring on the corrected sum of squares and variance inflation factor of the product variable while maintaining the equivalence between the two residual sums of squares for the regression of the product term on the two predictor variables. Thus the resulting test statistic remains unchanged regardless of the obvious modification of multicollinearity with mean centring. These findings provide a clear understanding and demonstration on the diverse impact of mean centring in MMR applications.
The sample squared multiple correlation coefficient is widely used for describing the usefulness of a multiple linear regression model in many areas of science. In this article, the author considers the problem of estimating the squared multiple correlation coefficient and the squared cross-validity coefficient under the assumption that the response and predictor variables have a joint multinormal distribution. Detailed numerical investigations are conducted to assess the exact bias and mean square error of the proposed modifications of established estimators. Notably, the positive-part Pratt estimator and the synthesis of Browne and positive-part Pratt estimators are recommended in the estimation of squared multiple correlation coefficient and squared cross-validity coefficient, respectively, for their overall advantages of incurring the least amount of statistical discrepancy and computational requirement.
A direct extension of the approach described in Self, Mauritsen, and Ohara (1992, Biometrics 48, 31-39) for power and sample size calculations in generalized linear models is presented. The major feature of the proposed approach is that the modification accommodates both a finite and an infinite number of covariate configurations. Furthermore, for the approximation of the noncentrality of the noncentral chi-square distribution for the likelihood ratio statistic, a simplification is provided that not only reduces substantial computation but also maintains the accuracy. Simulation studies are conducted to assess the accuracy for various model configurations and covariate distributions.
The intraclass correlation coefficient (ICC)(2) index from a one-way random effects model is widely used to describe the reliability of mean ratings in behavioral, educational, and psychological research. Despite its apparent utility, the essential property of ICC(2) as a point estimator of the average score intraclass correlation coefficient is seldom mentioned. This article considers several potential measures and compares their performance with ICC(2). Analytical derivations and numerical examinations are presented to assess the bias and mean square error of the alternative estimators. The results suggest that more advantageous indices can be recommended over ICC(2) for their theoretical implication and computational ease.
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