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An efficient method to identify whether mild cognitive impairment (MCI) has progressed to Alzheimer’s disease (AD) will be beneficial to patient care. Previous studies have shown that magnetic resonance imaging (MRI) has enabled the assessment of AD progression based on imaging findings. The present work aimed to establish an algorithm based on three features, namely, volume, surface area, and surface curvature within the hippocampal subfields, to model variations, including atrophy and structural changes to the cortical surface. In this study, a new biomarker, the ratio of principal curvatures (RPC), was proposed to characterize the folding patterns of the cortical gyrus and sulcus. Along with volumes and surface areas, these morphological features associated with the hippocampal subfields were assessed in terms of their sensitivity to the changes in cognitive capacity by two different feature selection methods. Either the extracted features were statistically significantly different, or the features were selected through a random forest model. The identified subfields and their structural indices that are sensitive to the changes characteristic of the progression from MCI to AD were further assessed with a multilayer perceptron classifier to help facilitate the diagnosis. The accuracy of the classification based on the proposed method to distinguish whether a MCI patient enters the AD stage amounted to 79.95%, solely using the information from the features selected by a logical feature selection method.

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The density of collagen fibers are automatically evaluated by the proposed algorithm based on enhanced Frangi filter. In optical virtual biopsy, Second Harmonic Generation (SHG) microscopy has been developed and applied to observe collagen fibers in the dermal layer of the human skin. The density of collagen fibers is a feature to describe the condition of collagen fibers which can provide indicator for the early pathological diagnosis and aging characteristic in SHG images. The proposed algorithm is capable of objectively and effectively reflecting that the distributions of collagen fibers are close or loose in virtual biopsy images as revealed by the experimental results. Moreover, the proposed method provides insight into identifying the correlation between the early symptoms of diseases and the density of collagen fibers.

This paper provides a motion-based contentadaptive depth map enhancement algorithm to enhance the quality of the depth map and reduce the artifacts in the synthesized views. The proposed algorithm extracts depth cues from the motion distribution at the specific scenario of camera movement to align the distribution of depth and motion. In real world scenarios, when the camera is panning in horizontal direction, the nearer distance between the object and the camera, the larger motion will be, and vice versa; therefore, we could interpret the depth from motion in this. Moreover, in the scenario of fixed camera, the depth cue from motion could be derived in the same approach, and the depth variation within one moving object shall be small. Hence, the depth values of moving object should not be rapidly changing. In addition, this paper also employs the bi-directional motion-compensated infinite impulse response low-pass filter to stabilize the consistency of depth maps over time. As a consequence, the algorithm so introduced not only aligns the depth map to depth cues from motion but also enhance stability and consistency of depth maps in the spatial-temporal domain. Experiment results via enhanced depth maps show that the synthesized results would be better in both objective and subjective measurement in comparison with the results using original depth maps and the state-of-the-art depth enhancement algorithms.