The present report shows that the frequent mutations described in the thyroid hormone receptor worldwide are also present in the Brazilian population, which is characterized by a variable ethnic background.
Using the current methods on hormone and biochemical analysis, we standardized the response of many parameters to TRH stimulation test after sequential and graded T(3) suppression test in normal subjects. Our data suggest that the evaluation of the responses of the hypothalamus-pituitary axis to TRH test as well as the impact of L-T(3) on peripheral tissues were not modified by the current methods.
O paradigma da biologia molecular é definido pelo dogma central, o qual é basicamente subdivido em: replicação do DNA (ácido desoxirribonucléico), que permite a perpetuação da informação gênica; transcrição, que converte a informação do DNA em uma fita de RNA (ácido ribonucléico) complementar; e tradução, que converte a informação contida no RNAm (ácido ribonucléico mensageiro) em proteínas. Tais processos ocorrem por meio do código genético, o qual é composto por conexões entre códons e seus respectivos aminoácidos. [...]
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