A retrospective analysis of six cases of central nervous system paracoccidioidomycosis, all but one proven by biopsy and surgery, was carried out to study the CT and clinical data and pathological correlation. Most of the patients were from the country. Headache, vomiting, seizures and hemiparesis were the most frequent symptoms. Papilloedema was present in four patients with raised intracranial pressure. Five patients had chronic lung disease and two with advanced systemic disease, skin and mucous membrane lesions were also observed. The neurological disturbance was sometimes the presenting features and the diagnosis was discovered incidentally after surgery. Both solitary and multiple parenchymal lesions were observed and the cerebral hemispheres were more commonly involved in four patients. Local meningeal involvement was observed in one with a single cortical granuloma. We emphasise the usefulness of CT, showing a rounded or lobulated mass with an isodense or radiolucent centre after contrast enhancement, surrounded by an irregular wall of varying thickness. There was always moderate oedema, extending peripherally. Other infections or neoplastic diseases may present similar findings. Preoperative diagnosis should rest on integration of clinical data, chest films, laboratory and neuroimaging studies.

RESUMO.O objetivo deste estudo foi identificar as alterações dos marcadores bioquímicos de danos hepáticos em cães naturalmente infectados por Leishmania sp. de acordo com as diferentes formas clínicas apresentadas por esses animais. Sangue de 41 cães soro-reagentes nos testes de ELISA e positivos nos testes imunocromatográfico e parasitológico de linfonodo foram colhidos por venopunção e acondicionados em tubo sem anticoagulante para obtenção de soro e mensuração de colesterol total, triglicerídeos, ureia, fosfatase alcalina, gamma glutamiltransferase, alanina aminotransferase, proteínas totais e albumina. Realizou-se a estratificação em grupos de acordo com a sintomatologia clínica, em assintomáticos (7/41), oligossintomáticos (15/41) e sintomáticos (19/41). Hiperglobulinemia, hiperproteinemia e diminuição da razão albumina:globulina foram constatadas em todos os grupos com diferença estatística para albumina (2,87 ± 0,45 g/dL). Colesterol, fosfatase alcalina, alanina aminotransferase e gamma glutamiltransferase permaneceram dentro dos intervalos de normalidade. As alterações encontradas nos marcadores bioquímicos de danos hepáticos sugerem que a leishmaniose visceral deve ser incluída no diagnóstico diferencial das hepatopatias, principalmente, nas áreas endêmicas para a enfermidade. Palavras chave: Biomarcadores, canino, enzimas, hepatopatia, Leishmania Behavior of biochemical markers of hepatic injury in dogs with visceral leishmaniasisABSTRACT. The aim of this study was to identify the changes in biochemical markers of liver damage in dogs naturally infected by Leishmania sp. according to different forms presented. Blood sample of 41 dogs were seropositive in ELISA test and positive in the immunoassay tests and lymph node parasitological were collected by venipuncture of the jugular vein and placed in tube without anticoagulant to obtain serum and measurement of total cholesterol, triglycerides, urea, alkaline phosphatase, gamma glutamyl transferase, alanine aminotransferase, total protein and albumin. Stratification was held in groups, according to clinical symptoms in asymptomatic (7/41), oligosymptomatic (15/41) and symptomatic (19/41). Hyperglobulinemia, hyperproteinemia and decreased the ratio A:G were observed in all groups, and no statistically significant difference between symptomatic animals in relation to others was observed for albumin (2.87 ± 0.45 g / dL). The average cholesterol values, alkaline phosphatase, alanine aminotransferase and gamma

Trypanosomiasis caused by Trypanosoma evansi can seriously affect both domestic and wild animals. This article reports on an outbreak of canine trypanosomiasis on a farm in the Pantanal region of Brazil. The farm had 38 dogs, 20 of which died before receiving veterinary care. The remaining 18 dogs were underwent anamnesisn, clinical examination, hematological and biochemical evaluations. Blood smears and PCR analysis were performed for the diagnosis. The treatment protocols used according to the clinical recovery or parasitological cure of the dogs, using diminazene diaceturate, isometamidium chloride or quinapyramine sulfate. Post-treatment parasitological evaluation was performed by the microhematocrit technique. 7/18 dogs were PCR positive for T. evansi (confirmed by sequencing). There was clinical findings, which were consistent with both the acute and chronic stages of the disease in dogs. The infected dogs all exhibited at least one clinical sign of the disease. The hematological findings were compatible with trypanosomiasis, highlighting the hypochromic microcytic anemia as the main outcome. No treatment protocol was fully effective and the prolonged use of diminazene diaceturate caused the death of an animal. The trypanosomiasis can cause high rates of morbidity and mortality in dogs and difficulty in establishment an effective and safe therapeutic protocol.

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RESUMO.Vários fatores como desmatamento e expansão da agricultura e pecuária tem promovido o contato próximo entre animais selvagens e domésticos, levando ao compartilhamento de patógenos, dentre eles o Cytauxzoon felis. O objetivo com este trabalho é relatar um caso de cytauxzoonose em Puma concolor de vida livre proveniente da região sudoeste de Mato Grosso do Sul, Brasil. O diagnóstico foi obtido por meio de microscopia de sangue periférico e reação em cadeia da polimerase, que neste relato, caracterizou-se como achado acidental, uma vez que manifestações clínicas associadas à doença não foram observadas. A detecção de Cytauxzoon felis alerta para a necessidade de estabelecer a importância epidemiológica dos animais selvagens e o risco que representam para as populações domésticas e selvagens de cativeiro em relação aos patógenos transmitidos por carrapatos. Palavras chave: cytauxzoonose, diagnóstico, piroplasmídeos, felino selvagem Natural infection by Cytauxzoon felis in brown ounce (Puma concolor) of free life from the southwest region of Mato Grosso do Sul, BrazilABSTRACT. Several factors such as deforestation and expansion of agriculture and livestock has promoted the close contact between wild and domestic animals, leading to the sharing of pathogens, including the Cytauxzoon felis. The aim of this study is to report a case of cytauxzoonose in a free-living Puma concolor from the southwest region of Mato Grosso do Sul, Brazil. The diagnosis was obtained through microscopy of peripheral blood smear and polymerase chain reaction, that in this report, was characterized as accidental finding, since clinical manifestations associated to disease were not observed. The

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Theileria equi is a tick-borne piroplasm considered endemic in equines in Brazil. The cohabitation of domestic and wild animals in areas of extensive cattle breeding favors the close contact between different species and the sharing of vectors and, consequently, pathogens. We report the natural infection of a young South American tapir ( Tapirus terrestris ) by T. equi in Mato Grosso do Sul, Brazil. Although it was not possible to associate the clinical and hematologic status of the animal with the infection by the protozoan parasite, our report represents an alert on the sharing of pathogens between domestic and wild animals.