Objective: This paper highlighted the effect of selected soil containing metals, viz. Cd, Cr, Cu, Fe, Ni, Pb and Zn on the biochemical compositions and antioxidant activity in leaf of 20 years old two Cassia fistula L. (CF) cultivars. The leaf samples were collected from CF grown on road sides from the states of Maharashtra and Karnataka in India. Methods: Antioxidant activity and total phenol contents from methanolic and aqueous leaf extract were evaluated by assays like oxygen radical absorbance capacities (ORAC), 2, 2 / -Azino-bis (3-ethylbenzothiozoline-6-sulphonic acid) diammonium salt (ABTS) and folin-ciocalteu reagent methods respectively. Maximum dose dependent antioxidant activity was observed in methanol leaf extract of both the cultivars, but marginal variation observed in antioxidant activity. Results: The result revealed that total phenolic content was maximum in the methanolic leaf extract (11.40 ± 0.37 mg g −1 of gallic acid equivalent). A positive correlation between antioxidant activity and total phenol compounds was noticed from both the samples. Furthermore a significant correlation was observed between element contents and antioxidant activities. Conclusion: This was may be due to elements like Fe, Cu, and Zn for accumulation of secondary constituents in the methanolic leaf extract that are major contributors to the antioxidant potential of CF. There were no other heavy metals (Ni, Cd, Pb and Cr) reported in both the samples.
The present investigation was carried out to evaluate the hypolipidemic activity of methanolic and aqueous leaf extracts of Cassia fistula (CF) Linn (Family: Fabaceae) on atherogenic diet (2% cholesterol, 1% Choline Chloride and 2% Lard) induced Male Sprauge-Dawley rats for the period of 21 days. The rats receiving the treatment with leaf methanol and aqueous extract of CF showed significant (P < 0.001) reduction in total cholesterol (TC), triglycerides (TG), High density lipoprotein (HDL), lipid peroxidation (LPO) and other parameters at dose dependent manner but the effect was less than the standard drug Atorvastatin. The results revealed the effectiveness of CF plant against hyperlipidemic activity.
Introduction:The present study was aimed to evaluate nootropic activity of Limonia acidissima on rats.
Materials and Methods:Methanolic extract of Limonia acidissima was used to evaluate nootropic activity, piracetam (200 mg/kg, i.p.) was used as standard and scopolamine (1 mg/kg, i.p.) was used to induce amnesia. Effect of drugs on learning and memory of rats was evaluated by using Y-maze task and elevated plus maze on scopolamine induced amnesia models.Locomotor activity was performed using actophotometer. Also, levels of acetylcholinestrease enzyme including histopathological study of rat brain were carried out.Results: Methanolic extract of Limonia acidissima showed increase in the alternation of behaviour response and percentage spontaneous alteration with Y-maze task. While in elevated plus maze scopolamine induced amnesia model, methanolic extract of Limonia acidissima showed decreased in transfer latency, which is an indicative of cognition improvement.Methanolic extract increases locomotor activity in rats and decreases the levels of acetylcholinestrease enzyme significantly. The histopathological study with both low and high dose of extract showed effective regenerative score as compared to other group.
Conclusion:The results suggested that the administration of methanolic extract of Limonia acidissima enhances learning and memory in different experimental model. The histopathological study reveals nero-protective property of extract. The study indicates that the extract may be used in the treatment of Alzheimer disease.
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