The satellite-based measurement-device-independent quantum key distribution can promote the realization of quantum communication networks. Under the condition of the limited data set, it is necessary to optimize all parameters. For communication networks, real-time prediction and optimization are also indispensable. With the development of machine learning, cross-combination with machine learning has also become the mainstream of parameter optimization in various disciplines. This paper discusses the asymmetric MDI-QKD based on the satellite in the case of statistical fluctuations, and uses the local search algorithm to achieve full parameter optimization under the condition of considering the probability of sending the signal. Compared with fixed related parameters, the key rate is increased by an order of magnitude. On this basis, random forest is used to predict the high-precision optimal parameters, thereby eliminating the simulation and iteration required by the search method to meet the real-time optimization of the future QKD network.
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