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MicroRNAs (miRNAs) play a vital role in the onset and development of many diseases, including cancers.
Emerging evidence shows that numerous miRNAs have the potential to be used as diagnostic biomarkers for cancers, and
miRNA-based therapy may be a promising therapy for the treatment of malignant neoplasm. MicroRNA-145 (miR-145)
has been considered to play certain roles in various cellular processes, such as proliferation, differentiation and apoptosis,
via modulating expression of direct target genes. Recent reports show that miR-145 participates in the progression of
digestive system cancers, and plays crucial and novel roles for cancer treatment. In this review, we summarize the recent
knowledge concerning the function of miR-145 and its direct targets in digestive system cancers. We discuss the potential
role of miR-145 as valuable biomarkers for digestive system cancers and how miR-145 regulates these digestive system
cancers via different targets to explore the potential strategy of targeting miR-145.
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