Gallic acid (GA) is a natural ingredient in functional foods, which has various health‐promoting and antitumour effects. Peptidyl‐prolyl cis/trans isomerase Pin1 plays an important role in preventing the development of some malignant tumours. However, whether there was an interaction between Pin1 and GA remains unknown. In this work, the binding information of GA and Pin1 was investigated systematically using multiple spectral and computational methods. GA bound to Pin1 directly with moderate binding affinity in the order of 104 mol/L, therefore decreasing the activity of Pin1. Also, the binding process of GA to Pin1 was driven through weak van der Waals forces, hydrogen bonds, and electrostatic forces. In addition, the important residues Lys63, Arg68, and Arg69 played a significant role in maintaining the binding stability between Pin1 and GA. Interestingly, GA reduced the activity of Pin1 by affecting its conformational characteristics. Our present work showed that GA binds to Pin1 and inhibits its activity, affecting its structural and functional properties, which may contribute to the therapy of Pin1‐related diseases.
In this paper, the research on properties of existing main structural lightweight aggregate (LWA) in the China Pearl River Delta as well as the application of corresponding structural lightweight aggregate concrete (LWAC) were introduced. In the application of structural LWAC, this paper emphasizes the design, manufacturing, construction and economic analysis for application of precast LWAC facade of Hong Kong. As the research deepens, structural LWAC has been gradually accepted by construction industry in Pearl River Delta. Experiment research and engineering practice has proved that the mechanical properties and durability of structural LWAC can completely meet the engineering requirements.
In this paper, a phase-change-material/lightweight aggregate (PCM-LWA) composite thermal energy storage material was prepared by absorbing the lauryl alcohol, which is one kind of phase change materials, into porous lightweight aggregates (LWAs) that have an excellent absorbability. In such a composite, the lauryl alcohol serves as a latent heat storage material and the porous lightweight aggregate acts as the supporting material. In order to prevent the melted lauryl alcohol leak from the porous LWAs, surface seal processing for the PCM-LWA was necessary. In this research, pure cement paste and polymer modified cement paste were used to seal the PCM-LWA surface. Through comparison between the differential scanning calorimetry (DSC) tests for lauryl alcohol and PCM-LWA, it can be known that the solid-liquid phase change temperature of the composite PCM-LWA was slightly higher than that of the lauryl alcohol, and latent heat of the PCM-LWA was smaller than that of the pure PCM.
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