We included 39,524 COVID-19 Omicron and 51,481 Delta cases reported in Norway from December 2021 to January 2022. We estimated a 73% reduced risk of hospitalisation (adjusted hazard ratio: 0.27; 95% confidence interval: 0.20–0.36) for Omicron compared with Delta. Compared with unvaccinated groups, Omicron cases who had completed primary two-dose vaccination 7–179 days before diagnosis had a lower reduced risk than Delta (66% vs 93%). People vaccinated with three doses had a similar risk reduction (86% vs 88%).

We consider classically scale-invariant extensions of the Standard Model (CSI ESM ) which stabilise the Higgs potential and have good dark matter candidates. In this framework all mass scales, including electroweak and dark matter masses, are generated dynamically and have a common origin. We consider Abelian and non-Abelian hidden sectors portally coupled to the SM with and without a real singlet scalar. We perform a careful analysis of RG running to determine regions in the parameter space where the SM Higgs vacuum is stabilised. After combining this with the LHC Higgs constraints, in models without a singlet, none of the regained parameter space in Abelian ESMs, and only a small section in the non-Abelian ESM survives. However, in all singlet-extended models we find that the Higgs vacuum can be stabilised in all of the parameter space consistent with the LHC constraints. These models naturally contain two dark matter candidates: the real singlet and the dark gauge boson in non-Abelian models. We determine the viable range of parameters in the CSI ESM framework by computing the relic abundance, imposing direct detection constraints and combining with the LHC Higgs constraints. In addition to being instrumental in Higgs stabilisation, we find that the singlet component is required to explain the observed dark matter density.

The Standard Model with an added Higgs portal interaction and no explicit mass terms is a classically scale-invariant theory. In this case the scale of electroweak symmetry breaking can be induced radiatively by the Coleman-Weinberg mechanism operational in a hidden sector, and then transmitted to the Standard Model through the Higgs portal. The smallness of the generated values for the Higgs vev and mass, compared to the UV cutoff of our classically scale-invariant effective theory, is naturally explained by this mechanism.We show how these classically conformal models can generate the baryon asymmetry of the Universe without the need of introducing mass scales by hand or their resonant finetuning. The minimal model we consider is the Standard Model coupled to the Coleman-Weinberg scalar field charged under the U (1) B−L gauge group. Anomaly cancellation requires automatic inclusion of three generations of right-handed neutrinos. Their GeV-scale Majorana masses are induced by the Coleman-Weinberg field and lead to the generation of active neutrino masses through the standard see-saw mechanism. Leptogenesis occurs via flavour oscillations of right-handed sterile neutrinos and is converted to the baryon asymmetry by electroweak sphalerons. * valya. khoze and g.o.i.ro@durham.ac.uk arXiv:1307.3764v3 [hep-ph] 26 Sep 2013 1 An implementation of the cosmological inflation mechanism and the inclusion of the dark matter candidate in the classically scale-invariant extended Standard Model is considered in the follow-up paper.2 In what follows we do not distinguish between |φ| 2 , |φ| 2 and | φ | 2 .

In a secluded dark sector which is coupled to the Standard Model via a Higgs portal interaction we arrange for the existence of 't Hooft-Polyakov magnetic monopoles and study their implications for cosmology. We point out that a dark sector which can accommodate stable monopoles will also contain massless dark photons γ as well as charged massive vector bosons W ± . The dark matter in this scenario will be a combination of magnetically and electrically charged species under the unbroken U(1) subgroup of the dark sector. We estimate the cosmological production rate of monopoles and the rate of monopole-anti-monopole annihilation and conclude that monopoles with masses of few hundred TeV or greater, can produce sizeable contributions to the observed dark matter relic density. We scan over the parameter space and compute the relic density for monopoles and vector bosons. Turning to dark photons, we compute their contribution to the measured density of relativistic particles N eff and also apply observational constraints from the Bullet cluster and other large scale galaxies on long-range interactions of monopoles and of dark vector bosons. At scales relevant for dwarf galaxies we identify regions on the parameter space where self-interacting monopole and vector dark mater components can aid solving the core-vs-cusp and the too-big-to-fail problems.

Understanding the epidemic growth of the novel SARS-CoV-2 Omicron variant is critical for public health. We compared the ten-day secondary attack rate (SAR) of the Omicron and Delta variants in households using Norwegian contact tracing data, December 2021 - January 2022. Omicron SAR was higher than Delta, with a relative risk (RR) of 1.41 (95% CI 1.27-1.56). We observed increased susceptibility to Omicron infection in household contacts compared to Delta, independent of contacts’ vaccination status. Among three-dose vaccinated contacts, the mean SAR was lower for both variants. We found increased Omicron transmissibility from primary cases to contacts in all vaccination groups, except 1-dose vaccinated, compared to Delta. Omicron SAR of three-dose vaccinated primary cases was high, 46% vs 11 % for Delta. In conclusion, three-dose vaccinated primary cases with Omicron infection can efficiently spread in households, while three-dose vaccinated contacts have a lower risk of being infected by Delta and Omicron.

Understanding the rapid epidemic growth of the novel SARS-CoV-2 Omicron variant is critical for public health management. We compared the secondary attack rate (SAR) of the Omicron and Delta variants in households using Norwegian contact tracing data from December 2021 to January 2022. Omicron SAR was higher (51%) than Delta (36%), with a relative risk (RR) of 1.41 (95% CI 1.27–1.56). We observed increased susceptibility to Omicron infection in household contacts compared to Delta independent of vaccination status; however, considering booster vaccinated contacts, the mean SAR was lower for both variants. We found increased Omicron transmissibility in all vaccination groups of primary cases, except partially vaccinated, compared to Delta. In particular, Omicron SAR for boosted primary cases was high, 46% vs 11% for Delta (RR 4.34; 95% CI 1.52–25.16). In conclusion, booster doses decrease the infection risk of Delta and Omicron but have limited effect in preventing Omicron transmission.

Background COVID-19 vaccines have been crucial in the pandemic response and understanding changes in vaccines effectiveness is essential to guide vaccine policies. Although the Delta variant is no longer dominant, understanding vaccine effectiveness properties will provide essential knowledge to comprehend the development of the pandemic and estimate potential changes over time. Methods In this population-based cohort study, we estimated the vaccine effectiveness of Comirnaty (Pfizer/BioNTech; BNT162b2), Spikevax (Moderna; mRNA-1273), Vaxzevria (AstraZeneca; ChAdOx nCoV-19; AZD1222), or a combination against SARS-CoV-2 infections, hospitalisations, intensive care admissions, and death using Cox proportional hazard models, across different vaccine product regimens and age groups, between 15 July and 31 November 2021 (Delta variant period). Vaccine status is included as a time-varying covariate and all models were adjusted for age, sex, comorbidities, county of residence, country of birth, and living conditions. Data from the entire adult Norwegian population were collated from the National Preparedness Register for COVID-19 (Beredt C19). Results The overall adjusted vaccine effectiveness against infection decreased from 81.3% (confidence interval (CI): 80.7 to 81.9) in the first 2 to 9 weeks after receiving a second dose to 8.6% (CI: 4.0 to 13.1) after more than 33 weeks, compared to 98.6% (CI: 97.5 to 99.2) and 66.6% (CI: 57.9 to 73.6) against hospitalisation respectively. After the third dose (booster), the effectiveness was 75.9% (CI: 73.4 to 78.1) against infection and 95.0% (CI: 92.6 to 96.6) against hospitalisation. Spikevax or a combination of mRNA products provided the highest protection, but the vaccine effectiveness decreased with time since vaccination for all vaccine regimens. Conclusions Even though the vaccine effectiveness against infection waned over time, all vaccine regimens remained effective against hospitalisation after the second vaccine dose. For all vaccine regimens, a booster facilitated recovery of effectiveness. The results from this support the use of heterologous schedules, increasing flexibility in vaccination policy.

Background: Complete and timely health information is essential to inform public health decision-