Şenses-Dinç G, Özçelik U, Çak T, Doğru-Ersöz D, Çöp E, Yalçın E, Çengel-Kültür E, Pekcan S, Kiper N, Ünal F. Psychiatric morbidity and quality of life in children and adolescents with cystic fibrosis. Turk J Pediatr 2018; 60: 32-40. The aim of this study was to investigate psychiatric disorders, depression and anxiety levels, and quality of life in children and adolescents with cystic fibrosis (CF), and to compare them with those of children with non-cystic fibrosis (non-CF) bronchiectasis and healthy controls. A total of 103 children and adolescents aged 7-16 years (35 CF, 28 non-CF bronchiectasis, 40 healthy) were evaluated using The Schedule for Affective Disorders and Schizophrenia for School Aged Children (K-SADS), The Child Depression Inventory (CDI), The State-Trait Anxiety Inventories for Children (STAI-C) and the Pediatric Quality of Life Inventory (PedsQL)-C. The three groups were not statistically different with respect to age, sex, and familial sociodemographic variables. 80% of the children and adolescents in the CF group were diagnosed with a psychiatric disorder, which was significantly more compared to those of the two other groups. The CF group had significantly greater rates of depressive and oppositional defiant disorder and the non-bronchiectasis group had a significantly greater rate of anxiety disorder than the control group. The depression and anxiety symptom levels were significantly greater and the quality of life levels significantly lower in both the CF and non-CF bronchiectasis groups than the healthy controls. In the CF group, the presence of any associated psychiatric disorder led to significantly lower total and psychosocial quality of life scores. In conclusion, CF is associated with poorer QOL in childhood. In order to improve quality of life in CF, the psychiatric conditions of children and adolescents should also be evaluated and their follow-up and treatment should involve a multidisciplinary team approach.

Abstract"ttention-deficit/hyperactivity disorder "DHD is a neurodevelopmental disorder characterized by inattention, impulsivity, and hyperactivity of core symptoms, affecting -% of school age children, as well as % of adults.Quality of Life QoL is an individual perception in regard to his/her position in life, in the context of culture and value systems in which they live, and in relation to their goals, expectations, standards and concerns. Then it has a multidimensional concept, the core of which consists of the physical, psychological, cognitive, and social aspects of functioning.Several studies on QoL in "DHD have been published pointing out that QoL domains in "DHD have been found to be negatively affected compared to the healthy persons. This situation suggests that "DHD not only affects academic achievements of a person but it also has a deteriorating effect on all aspects of life, including social and occupational. Mostly used pharmacological agents are atomoxetine, methylphenidate and other stimulants related to QoL and "DHD context. These agents of "DHD treatments have been correlated with an improvement in QoL scores. Non-pharmacological interventions and their effects on QoL in patients with "DHD or the effectiveness of combined treatment modalities should be carried out in the near future.