The features of the interaction of the anthelmintic drug adbendazole with citrus pectin have been studied. By the methods of potentiometric titration, viscometry, IR spectroscopy, and X-ray phase analysis it was shown that the interaction takes place in the narrow pH range using salt and hydrophobic bonds. It was established that the obtained polymer complex of albendazole "Alpec" Section 2. Chemistry 24 exhibits the more pronounced anthelmintic activity compared to the initial albendazole. It have been found that the LD 50 of Alpec is 680 (601,8 ÷ 768,4) mg.kg -1 , which is almost 1,5 times higher than the LD 50 of albendazole. The resulting polymer form of albendazole can be recommended for the application in medicine and veterinary practice.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.