Today, cancer is appearing as a major unsolved health problem. Basicly, surgery, chemotherapy and hormone therapy models are used in the treatment of cancer.Basic procedures and drugs used in the treatment of cancer are thought to be insufficient. These treatments have some side effects and they take a long time.Due to the problems encountered in the treatment of cancer in the recent years, alternative methods of treatment are being researched. For this purpose the effect of herbal, synthetic and fungus organisms against various types of cancer is being investigated.
Acrylamide is a compound that occurs with high temperature during food processing and causes oxidative damage. Recently, the importance of antioxidative components is increasing to prevent oxidative damage. Lactoferrin is an antioxidant protein mainly found in milk. Therefore, the aim of this study is to determine the dosedependent protective effects of lactoferrin on oxidative damage caused by acrylamide.In this study, HepG2 cell lines were treated with lactoferrin doses (0, 25, 50, 100µM) and half maximal inhibitory concentration of acrylamide. After 24 hours malondialdehyde, superoxide dismutase, catalase and glutathione reductase levels were measured.Acrylamide signifi cantly increased malondialdehyde levels in HepG2 cells compared to the control group; however, catalase, superoxide dismutase and glutathione reductace signifi cantly reduced. On the other hand, added lactoferrin doses (50-100µM) signifi cantly reduced lipid peroxidation levels. Besides, it was found that glutathione reductase, catalase and superoxide dismutase levels signifi cantly increased. As a result, the protective effect of lactoferrin against the oxidative damage caused by acrylamide in HepG2 cells was determined. This effect is thought to be due to the antioxidant capacity of lactoferrin. In this context, it is recommended that more studies are carried out on the mechanism of action of lactoferrin on oxidative stress caused by acrylamide.
Environmental conditions like aridity, salinity, extreme changes in temperatures, extreme precipitations etc. cause abiotic stress factors and influence the growth and propagation of
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