A series of 6-thiocyanatopurine derivatives introduced with different alkyl groups in position 9 was synthesized. The structures of the synthesized compounds were evaluated via spectroscopic methods and elemental methods of analyses. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gram-negative bacteria and for their antifungal activities against yeast strains. All the synthesized compounds showed better antibacterial activities against Gram-positive bacteria compared to Gram-negative bacteria. DNA interactions with pBR322 DNA were determined. Most of the compounds caused conformational changes in DNA.Key words purine derivative; antimetabolite; antimicrobial activity; DNA interaction Purines are one of the most important classes of heterocyclic compounds in nature, fulfilling functional roles as nucleic acids, coenzymes, and constituents in metabolic processes, cell signaling, and energy storage.
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