The study was undertaken to evaluate the interest of cholesterol subclasses in the management of hypertensive patients recruited at University Hospital Yalgado Ouedraogo of Ouagadougou (Burkina Faso, West Africa). The distribution of hypertensive was reported as 45 (35.4%) without complications, 42 (33%) with cardiovascular complications and 40 (31.4%) with diabetes. Any difference in lipids profile was observed when balanced hypertensive was compared to non-balanced hypertensive. The total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and HDL3 cholesterol (HDL3C) were significantly higher in hypertensive compared to the control group (p<0.001). Significant decrease of TC and HDLC levels was observed in women within hypertensive group (p<0.05). The increase in triglyceride (TG) and low density lipoprotein cholesterol (LDLC) was significant in obese compared to non-obese. The HDLC level was higher (p<0.01) in treated hypertensive compared to untreated, particularly females. The HDLC increased significantly in treated hypertensive without complications (p<0.01). The TC and LDLC levels were higher in treated hypertensive with diabetes (p<0.05). The HDL2 cholesterol (HDL2C) was significantly lower in treated hypertensive with diabetes (p<0.05), and particularly in obese compared to non-obese. A significant decrease of HDL2C was observed in female stage 3 hypertensive (p<0.05). The HDL2C might be a better predictor of cardiovascular risks in hypertensive if the relationship between its decrease with severity of hypertension is confirmed by further studies.