Optical coherence tomography (OCT) is a growing imaging technique for real-time early diagnosis of digestive system diseases. As with other well-established medical imaging modalities, OCT requires validated imaging performance and standardized test methods for performance assessment. A major limitation in the development and testing of new imaging technologies is the lack of models for simultaneous clinical procedure emulation and characterization of healthy and diseased tissues. Currently, the former can be tested in large animal models and the latter can be tested in small animal disease models or excised human biopsy samples. In this study, a 23 cm by 23 cm optical phantom was developed to mimic the thickness and near-infrared optical properties of each anatomical layer of a human colon, as well as the surface topography of colorectal polyps and visual appearance compatible with white light endoscopy.
Optical Coherence Tomography (OCT) is an emerging medical imaging modality for luminal organ diagnosis. The non-constant rotation speed of optical components in the OCT catheter tip causes rotational distortion in OCT volumetric scanning. By improving the scanning process, this instability can be partially reduced. To further correct the rotational distortion in the OCT image, a volumetric data stabilization algorithm is proposed. The algorithm first estimates the Non-Uniform Rotational Distortion (NURD) for each B-scan by using a Convolutional Neural Network (CNN). A correlation map between two successive B-scans is computed and provided as input to the CNN. To solve the problem of accumulative error in iterative frame stream processing, we deploy an overall rotation estimation between reference orientation and actual OCT image orientation. We train the network with synthetic OCT videos by intentionally adding rotational distortion into real OCT images. As part of this article we discuss the proposed method in two different scanning modes: the first is a conventional pullback mode where the optical components move along the protection sheath, and the second is a self-designed scanning mode where the catheter is globally translated by using an external actuator. The efficiency and robustness of the proposed method are evaluated with synthetic scans as well as real scans under two scanning modes.
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