Background:Little is known about the substrate specificity of the essential P450 CYP121 from Mycobacterium tuberculosis. Results: CYP121 substrate analogues either display impaired binding to CYP121 or are poorly transformed by CYP121. Conclusion: CYP121 is a highly specific P450. Significance: This work contributes to the understanding of the function and the catalytic mechanism of CYP121 and provides novel data for the design of inhibitors.
New Yb(OTf)(3)-pyridylalkylamine complexes have been employed as chiral Lewis acids in the enantioselective Friedel-Crafts alkylation of indole derivatives with trifluoropyruvates. The influence of the substituents as well as the configuration of the ligands have been studied and allowed us to reach enantiomeric excesses up to 83%.
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