The antimalarial activities of ferrocenic compounds mimicking chloroquine and active upon chloroquine-resistant strains of Plasmodium falciparum were evaluated. Four 7-chloro-4-[[[2-[(N,N-substituted amino)methyl]ferrocenyl]methyl]amino]quinoline derivatives have been synthesized; one of them, 1a, showed high potent antimalarial activity in vivo on mice infected with Plasmodium berghei N. and Plasmodium yoelii NS. and was 22 times more potent against schizontocides than chloroquine in vitro against a drug-resistant strain of P. falciparum.

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1997organo-iron compounds organo-iron compounds S 7100 -176Enantioselective Synthesis of (R)-and (S)-1-Ferrocenylalkylamines. Reduction of Enantiopure Ferrocenylimines Obtained from Valinol and Phenylglycinol.-Two synthetic procedures leading to chiral ferrocenylaminoalcohols are developed starting from ferrocenylaldimines (I) and (IV) and from ferrocenylketimines (VI) and (VIII), respectively. Both diastereomers of the same compound can be obtained. The ferrocenylaminoalcohols undergo oxidative cleavage yielding the optically active title compounds (X) which are useful ligands for homogenous asymmetric catalysis. -(GLORIAN, G.; MA-CIEJEWSKI, L.; BROCARD, J.; AGBOSSOU, F.; Tetrahedron: Asymmetry 8 (1997) 3, 355-358; Lab. Catal. Heterog.