Most biological systems are formed by component parts that are to some degree interrelated. Groups of parts that are more associated among themselves and are relatively autonomous from others are called modules. One of the consequences of modularity is that biological systems usually present an unequal distribution of the genetic variation among traits. Estimating the covariance matrix that describes these systems is a difficult problem due to a number of factors such as poor sample sizes and measurement errors. We show that this problem will be exacerbated whenever matrix inversion is required, as in directional selection reconstruction analysis. We explore the consequences of varying degrees of modularity and signal-to-noise ratio on selection reconstruction. We then present and test the efficiency of available methods for controlling noise in matrix estimates.In our simulations, controlling matrices for noise vastly improves the reconstruction of selection gradients. We also perform an analysis of selection gradients reconstruction over a New World Monkeys skull database to illustrate the impact of noise on such analyses. Noise-controlled estimates render far more plausible interpretations that are in full agreement with previous results. K E Y W O R D S :Adaptation, models/simulations, morphological evolution, pleiotropy, quantitative genetics, selection-natural.The study of biological systems and its component parts, whether molecules, cells, tissues, organisms and its forming parts, and even species and their interactions, is rapidly converging to the central theme of modularity. This refers to the connections among some of the component parts of a biological system (genes or morphological traits, for example) and the lack of such associations among other parts of the same system. (Olson and Miller 1958;Berg 1960;Wagner et al. 2007). The notion that interacting parts are not independent is intuitive and appears early in the history of Biology (see Mayr 1982). Therefore, modularity is quickly becoming one of the central questions in modern biology (Wagner et al. 2007;Klingenberg 2008) and a point of convergence of various specialties and areas (Mathematics, Statistics, Genetics and Genomics, Evolutionary Biology, Ecology, Biochemistry, and Physiology).In biology, several types of modules have been recognized, including (1) functional, consisting of characters or features that act together on performing a task or function and are quasiautonomous in relation to other functional sets; (2) developmental, which corresponds to parts of an embryo that are relatively autonomous with respect to pattern formation and differentiation, or an autonomous signaling cascade; (3) variational, composed of characters that vary together and are relatively independent of other such sets (Wagner et al. 2007).The study of modularity is centered on statistical estimation of association among traits (Olson and Miller 1958;Berg 1960). Whether such association is measured by correlation, covariance, or distance/similarity measures, i...
We present an open source package for performing evolutionary quantitative genetics analyses in the R environment for statistical computing. Evolutionary theory shows that evolution depends critically on the available variation in a given population. When dealing with many quantitative traits this variation is expressed in the form of a covariance matrix, particularly the additive genetic covariance matrix or sometimes the phenotypic matrix, when the genetic matrix is unavailable and there is evidence the phenotypic matrix is sufficiently similar to the genetic matrix. Given this mathematical representation of available variation, the EvolQG package provides functions for calculation of relevant evolutionary statistics; estimation of sampling error; corrections for this error; matrix comparison via correlations, distances and matrix decomposition; analysis of modularity patterns; and functions for testing evolutionary hypotheses on taxa diversification.
Ecological interactions shape adaptations through coevolution not only between pairs of species but also through entire multispecies assemblages. Local coevolution can then be further altered through spatial processes that have been formally partitioned in the geographic mosaic theory of coevolution. A major current challenge is to understand the spatial patterns of coadaptation that emerge across ecosystems through the interplay between gene flow and selection in networks of interacting species. Here, we combine a coevolutionary model, network theory, and empirical information on species interactions to investigate how gene flow and geographical variation in selection affect trait patterns in mutualistic networks. We show that gene flow has the surprising effect of favoring trait matching, especially among generalist species in species-rich networks typical of pollination and seed dispersal interactions. Using an analytical approximation of our model, we demonstrate that gene flow promotes trait matching by making the adaptive landscapes of different species more similar to each other. We use this result to show that the progressive loss of gene flow associated with habitat fragmentation may undermine coadaptation in mutualisms. Our results therefore provide predictions of how spatial processes shape the evolution of species-rich interactions and how the widespread fragmentation of natural landscapes may modify the coevolutionary process.
Genetic and phenotypic variance/covariance matrices are a fundamental measure of the amount of variation and the pattern of association among traits for current investigations in evolutionary biology. Still, few methods have been developed to accomplish the goal of pinpointing in which traits two matrices differ most, hampering further works on the field. We here described a novel method for dissecting matrix comparisons. This method is called Selection Response Decomposition and is an extension of the random skewers in the sense that evolutionary responses produced by known simulated selection vectors are unfolded and then compared in terms of the direct and indirect responses to selection for any trait. We also applied the method in diverse case studies, illustrating its potential. Both theoretical matrices and empirical biological data were used in the comparisons made. In the theoretical ones, the method was able to determine exactly which traits were responsible for the known a priori differences between the matrices, as well as where matrices remained similar to each other. Similar support could be observed in comparisons carried on between matrices produced from empirical biological data, since reasonable and detailed interpretations could be made regarding matrix comparisons. SRD represents an excellent tool for matrix comparisons and should provide quantitative evolutionary biology with a new method for analyzing and comparing variance/covariance patterns.
Patterns of genetic covariance between characters (represented by the covariance matrix G G G) play an important role in morphological evolution, since they interact with the evolutionary forces acting over populations. They are also expected to influence the patterns expressed in their phenotypic counterparts (P P P), because of limits imposed by multiple developmental and functional restrictions on the genotype/phenotype map. We have investigated genetic covariances in the skull and mandible of the vesper mouse (Calomys expulsus) in order to estimate the degree of similarity between genetic and phenotypic covariances and its potential roots on developmental and functional factors shaping those integration patterns. We use a classic ad hoc analysis of morphological integration based on current state of art of developmental/functional factors during mammalian ontogeny and also applied a novel methodology that makes use of simulated evolutionary responses. We have obtained P P P and G G G that are strongly similar, for both skull and mandible; their similarity is achieved through the spatial and temporal organization of developmental and functional interactions, which are consistently recognized as hypothesis of trait associations in both matrices.
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