In recent years, different laboratories were interested in predicting the mixing time of a pharmaceutical powder. In fact, a nonhomogeneous mixture may lead to under dose and/or overdose of the active ingredient in the drug product. Our study is aimed toward using a new and revolutionary approach in the field of the processes "The Artificial Neural Networks" (ANN) by using the Neural Networks Toolbox TM derived from Matlab ® software. The validation of the neural network was assumed by studying others mixing p o w d e r s and then w e compared the experimental results to the data obtained by the neural network calculations. Experimental results were obtained from a non-destructive method (Image Analysis) which was used in order to characterize the homogeneity of powder mixture in a V-Blender as well as a Cubic Blender which are most used in the pharmaceutical industry. Keywords