Pyrazole derivativesPyrazole derivatives R 0180 1-N-Substituted Thiocarbamoyl-3-phenyl-5-thienyl-2-pyrazolines: Synthesis and Evaluation as MAO Inhibitors. -Compounds (IIIc)-(IIIf) inhibit MAO-B selectively and irreversibly. -(GOEKHAN, N.; YESILADA, A.; UCAR, G.; EROL, K.; BILGIN, A. A.; Arch. Pharm. (Weinheim, Ger.) 336 (2003) 8, 362-371; Dep. Pharm. Chem., Fac. Pharm., Hacettepe Univ., TR-06100 Ankara, Turk.; Eng.) -K. Woydowski 52-124

No abstract

Pyrazole derivatives R 0180Synthesis and Monoamine Oxidase Inhibitory Activities of 1-Thiocarbamoyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole Derivatives. -A variety of the title pyrazole derivatives (III) (10 examples) are synthesized and evaluated for their ability to selectively inhibit monoamine oxidase (MAO) in vitro. Derivatives (IIIc) and (IIIf) are found to be as potent as the standard clorgyline. -(PALASKA*, E.; AYDIN, F.; UCAR, G.; EROL, D.; Arch. Pharm. (Weinheim, Ger.) 341 (2008) 4, 209-215; Dep. Pharm. Chem., Fac. Pharm., Hacettepe Univ., TR-06100 Ankara, Turk.; Eng.) -R. Langenstrassen 31-149

The title chalcones are prepared and tested for their inhibitory activities towards human monoamine oxidase (hMAO).