Asymmetric hydrosilylation–transacylation of α-acyloxy β-enamino esters provided various α-hydroxyl-β-acylamido esters in good yields with good diastereoselectivities and enantioselectivities.
The first method for the reduction of a-keto substituted acrylate compounds by Hantzsch ester in water under the catalysis of thiourea has been developed. The products were isolated in moderate to high yields (38-95%). These products are important intermediates in the synthesis of a series of natural products and other biologically active molecules.
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