The first asymmetric total synthesis of rumphellclovane E, a clovane-type sesquiterpenoid, has been accomplished in eight steps from commercially available (R)-carvone. Key elements of the synthesis include Rh-catalyzed cyclopropanation, ironcatalyzed intramolecular reductive aldol reaction, and SmI 2mediated chemo-and diastereoselective reduction of the cyclopentanone.
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