The thermodynamic description of the Ti-U binary system is obtained by the CALPHAD method using Thermo-Calc software and based on the estimated thermodynamic properties using ion-bonding model and Miedema model as well as the experimental phase diagram information. The liquid, αU, βU, δTi, and γ phases are assumed to be substitutional solutions with Redlich-Kister formula for the expressions of their excess Gibbs energy. The intermetallic compound TiU2 is treated as a stoichiometric compound. The calculated phase equlibria are in good agreement with the estimated and available experimental phase diagram data.