This study introduces a supercapacitor hybrid energy storage system in a wind-solar hybrid power generation system, which can remarkably increase the energy storage capacity and output power of the system. In the specific solution, this study combines the distributed power generation system and the hybrid energy storage system, while using the static reactive power compensation system and the conductance-fuzzy dual-mode control method to increase output power in stages. At the same time, the optimal configuration model of the wind-solar hybrid power generation system is established using MATLAB/Simulink software. The output power of the microgrid to the wind-photovoltaic hybrid power generation system is calculated by simulation, and the optimization process of each component of the system is simulated. This study mainly uses the static reactive power compensation system and the conductance-fuzzy dual-mode control method to optimize the wind-solar hybrid power generation system. Using MATLAB software simulation verifies the feasibility and rationality of the optimal configuration of the system.
Combining MS-based proteomic data with network and topological features of such network would identify more clinically relevant molecules and meaningfully expand the repertoire of proteins derived from MS analysis. The integrative topological indexes representing 95.96% information of seven individual topological measures of node proteins were calculated within a protein-protein interaction (PPI) network, built using 244 differentially expressed proteins (DEPs) identified by iTRAQ 2D-LC-MS/MS. Compared with DEPs, differentially expressed genes (DEGs) and comprehensive features (CFs), structurally dominant nodes (SDNs) based on integrative topological index distribution produced comparable classification performance in three different clinical settings using five independent gene expression data sets. The signature molecules of SDN-based classifier for distinction of early from late clinical TNM stages were enriched in biological traits of protein synthesis, intracellular localization and ribosome biogenesis, which suggests that ribosome biogenesis represents a promising therapeutic target for treating ESCC. In addition, ITGB1 expression selected exclusively by integrative topological measures correlated with clinical stages and prognosis, which was further validated with two independent cohorts of ESCC samples. Thus the integrative topological analysis of PPI networks proposed in this study provides an alternative approach to identify potential biomarkers and therapeutic targets from MS/MS data with functional insights in ESCC.
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