Magnesium phosphate biomaterial, as an alternative to well-known calcium phosphate biomaterials, is an excellent candidate for biomedical applications, owing to its outstanding biocompatibility and biodegradability. Herein, we report a simple strategy for the rapid synthesis of magnesium phosphate hydrate nanosheets (MPHSs) using the microwave-assisted hydrothermal method. This method is facile, rapid, surfactant-free and environmentally friendly. The product shows an excellent ability to promote osteoblast MC-3T3 adhesion and spreading, which indicates high biocompatibility. Moreover, the asprepared MPHSs are explored for potential applications in the loading and release of the anticancer drug and protein adsorption, using docetaxel as a model anticancer drug and hemoglobin (Hb) as a model protein.The experiments indicate that the as-prepared MPHSs have a relatively high protein adsorption capacity and a high ability to damage tumor cells after loading docetaxel. Thus, the as-prepared MPHSs are promising for applications in various biomedical fields such as drug delivery and protein adsorption.

Microwave-assisted hydrothermal synthesis of porous hollow microspheres of amorphous calcium phosphate using adenosine triphosphate, CaCl2 and soybean lecithin is reported.