With the recent increase in complex coronary interventions including percutaneous coronary intervention (PCI) for chronic total occlusions and complex higher risk (and indicated) patients, the spectrum of potential periprocedural complications and their prompt management has become even more relevant. Vascular access-related problems remain the most prevalent of all PCI complications and with randomized controlled trial data from over 20,000 patients supporting the superiority of radial over femoral access in reducing bleeding and vascular complications, a default radial strategy should be promoted. The European Society of Cardiology guidelines have acknowledged this by giving a class 1 (level of evidence: A) recommendation for a radial approach for PCI. The US society guidelines, however, have thus far lagged behind. Each individual patient undergoing a PCI should be risk-stratified objectively using available risk prediction models based on patient comorbidities and anatomical and procedural complexities. Customized informed consent should therefore be provided to all patients and should include the potential risks from radiation injury. Here, we review the current data related to common periprocedural complications related to PCI.
INTRODUCTION: The anticoagulation and antiplatelet strategies of patients with high-risk ST-elevation myocardial infarction (STEMI) can be a difficult balance of risk, especially for those that require an intra-aortic balloon pump (IABP). The incidence of major bleeding in patients that require GP IIb/IIIa inhibitors and heparin is 8.3% compared to 4.9% in those treated with bivalirudin alone; however, the latter are at increased risk of in-stent thrombosis. While the guidelines support GP IIb/IIIa inhibitors in high-risk situations and heparin for IABP, these therapies further increase bleeding risk. To illustrate these management difficulties, we present a high-risk STEMI complicated by fatal pulmonary hemorrhage.
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